HDAC6 degrader 9c ( dHDAC6 9c )

Catalog No. M13585 CAS No. 2235382-05-3

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Datasheet

HNMR

HPLC

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Product Name

HDAC6 degrader 9c
Note

Research use only, not for human use.
Brief Description

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand.
Description

HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line.
Synonyms

dHDAC6 9c
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

2235382-05-3
Formula Weight

775.82
Molecular Formula

C37H45N9O10
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NO)CCCCCCC(N/N=C/C1=CC=C(OCCOCCOCCN2N=NC(CNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=C2)C=C1)=O
Chemical Name

(E)-8-(2-(4-(2-(2-(2-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide

1. Tan S, et al. Bioorg Med Chem. 2017 Aug 1;25(15):4123-4132.

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